Nicotine and Cognition in Cognitively Normal Older Adults
نویسندگان
چکیده
منابع مشابه
APOE modifies the association between Aβ load and cognition in cognitively normal older adults.
OBJECTIVE To determine the relationship between β-amyloid (Aβ) load as measured by [(11)C]-Pittsburgh compound B (PiB) PET and cognitive function in cognitively normal older adults. METHODS We studied 408 cognitively normal older adults who participated in the population-based Mayo Clinic Study of Aging (MCSA) from January 2009 through March 2011. The participants underwent PiB PET and neurop...
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OBJECTIVE In addition to the increasingly recognized role of physical exercise in maintaining cognition, exercise may influence Alzheimer's disease (AD) pathology, as transgenic mouse studies show lowered levels of AD pathology in exercise groups. The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound-B (PIB), amyloid-b...
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IMPORTANCE The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the association between AC medication use and neuroimaging biomarkers of brain metabolism and atrophy as a proxy for understanding the underlying biology of the clinical effects of AC medications. OBJECTIVE To asses...
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IMPORTANCE Criteria for preclinical Alzheimer disease (AD) propose β-amyloid (Aβ) plaques to initiate neurodegeneration within AD-affected regions. However, some cognitively normal older individuals harbor neural injury similar to patients with AD, without concurrent Aβ burden. Such findings challenge the proposed sequence and suggest that Aβ-independent precursors underlie AD-typical neurodege...
متن کاملPhysical (in)activity and cognition in cognitively impaired older people
Aging coincides with a decline in lower limb muscle strength (LLMS). Preserving LLMS may be considered a very important determinant of functional independence in the elderly. To maintain LLMS the question arises whether habitual physical activitys (HPAs) can prevent a decline in LLMS. This review aims to determine the relationship between HPAs throughout life and LLMS above age 50. Using releva...
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ژورنال
عنوان ژورنال: Frontiers in Aging Neuroscience
سال: 2021
ISSN: 1663-4365
DOI: 10.3389/fnagi.2021.640674